Impact of Cliff and Ord (1969, 1981) on Spatial Epidemiology

The influence in spatial epidemiology of the seminar work on autocorrelation by Cliff and Ord is discussed. Quantifying the evidence of spatial clustering was an important step in the development of modern statistical methods for analyzing spatial variations of diseases. Autocorrelation is nowadays mostly accounted for at a latent level within a hierarchical framework to small area disease mapping. The importance of accounting for autocorrelation in geographical correlation studies is also reviewed.