Genome-wide analysis identified 12 loci influencing human reproductive behaviour

Barban, Nicola and Tropf, Felix and Mills, Melinda (2016) Genome-wide analysis identified 12 loci influencing human reproductive behaviour. Nature Genetics, 48 (12). pp. 1462-1475. ISSN 1546-1718

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Abstract

The genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.

Item Type:Article
Subjects:1. Frameworks for Research and Research Designs > 1.18 Meta-Analysis
1. Frameworks for Research and Research Designs > 1.23 Interdisciplinary and Multidisciplinary Research
ID Code:4058
Deposited By: NCRM users
Deposited On:29 Nov 2017 14:25
Last Modified:29 Nov 2017 14:25

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